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Analysis Confirms Role of Endometriosis in Heightened Risk for Ovarian Cancer
Endometriosis increases risk for invasive ovarian cancer, an analysis of several international studies confirms, but the risk does not extend to all tumor subtypes. The results appear in the Lancet Oncology.
Researchers pooled data from 13 case-control studies performed within the Ovarian Cancer Association Consortium. In those studies, which included some 8000 women with invasive ovarian cancer and 13,000 controls, women self-reported whether they had a history of endometriosis.
Roughly 9% of women with invasive cancer reported a history of endometriosis, compared with 6% of controls. Women with a positive history were more likely to have clear-cell, endometrioid, and low-grade serous tumors, but the other two tumor subtypes (mucinous and high-grade serous) were not associated with endometriosis.
A commentator writes that because some of the tumor subtypes associated with endometriosis present at an early stage and thus could be resected, targeted screening could be considered for some women.
Lancet Oncology article (Free abstract)
Lancet Oncology comment (Subscription required)
Published in Physician's First Watch February 22, 2012
- hightened risk
Laurey Hallson, 22 Feb 2012 12:30 PM EST
Specialty: Obstetrics & Gynecology
Does this extrapolate to post tah bso for endometriosis to primary peritoneal cancer? Just wondering...if the endometriosis is so bad... [more]
- Endometriosis linked to higher Ovarian Cancer risk
Jose Gros-Aymerich, Retired, 24 Feb 2012 11:54 AM EST
May be the connection is thru changes in p53, a known tumor- supressor, that is abnormal in some endometriosis patients... [more]
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