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Exercise Plus Statin Therapy Associated with Reduced Mortality
Physical activity and statin use, both independently and combined, are associated with reduced mortality risk among patients with elevated cholesterol, according to a Lancet study.
Researchers prospectively collected data on roughly 10,000 veterans (mostly male) with dyslipidemia who underwent exercise tolerance tests. Over a median follow-up of 10 years, statin users had a mortality risk of 18.5%, while nonusers had a mortality risk of 27.7%. The mortality risk was reduced among the fittest participants, both among nonusers and users of statins.
The authors conclude: "Improved fitness is an attractive adjunct treatment to statins or an alternative when statins cannot be prescribed. The low exercise capacity (roughly 7 MET) associated with the aforementioned health benefits is clinically significant and reinforces the importance of physical activity for individuals with dyslipidemia."
LINK(S):
Lancet article (Free abstract)
Published in Physician's First Watch November 28, 2012
Reader Remarks:
Review and add to remarks on this article
- Not conclusive for women
Carolyn Thomas, 3 Dec 2012 11:11 AM EST
Specialty: Cardiovascular Disease
The study's conclusion "reinforces the importance of physical activity for individuals with dyslipidemia" should likely be corrected to read "MEN"... [more] - Exercise, Statins & Cholesterol
Dr Frank Rajan, Changanacherry, 17 Dec 2012 1:58 PM EST
Specialty: Emergency Medicine
Cholesterol has now been marginalized as a cause of IHD. Statins are therefore an unnecessary and potentially harmful medication, what... [more]
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