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Exercise Plus Statin Therapy Associated with Reduced Mortality
Physical activity and statin use, both independently and combined, are associated with reduced mortality risk among patients with elevated cholesterol, according to a Lancet study.
Researchers prospectively collected data on roughly 10,000 veterans (mostly male) with dyslipidemia who underwent exercise tolerance tests. Over a median follow-up of 10 years, statin users had a mortality risk of 18.5%, while nonusers had a mortality risk of 27.7%. The mortality risk was reduced among the fittest participants, both among nonusers and users of statins.
The authors conclude: "Improved fitness is an attractive adjunct treatment to statins or an alternative when statins cannot be prescribed. The low exercise capacity (roughly 7 MET) associated with the aforementioned health benefits is clinically significant and reinforces the importance of physical activity for individuals with dyslipidemia."
Lancet article (Free abstract)
Published in Physician's First Watch November 28, 2012
- Not conclusive for women
Carolyn Thomas, 3 Dec 2012 11:11 AM EST
Specialty: Cardiovascular Disease
The study's conclusion "reinforces the importance of physical activity for individuals with dyslipidemia" should likely be corrected to read "MEN"... [more]
- Exercise, Statins & Cholesterol
Dr Frank Rajan, Changanacherry, 17 Dec 2012 1:58 PM EST
Specialty: Emergency Medicine
Cholesterol has now been marginalized as a cause of IHD. Statins are therefore an unnecessary and potentially harmful medication, what... [more]
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