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Vitamins C and E Do Not Prevent Heart Disease in Men
Vitamins E and C do not prevent cardiovascular disease in men, JAMA reports online.
In the Physicians' Health Study II, some 14,600 male doctors aged 50 or older were randomized to receive vitamin E (400 IU every other day), vitamin C (500 mg daily), both, or placebos; 95% were free of cardiovascular disease at baseline.
During roughly 8 years' follow-up, vitamins E and C — either alone or in combination — did not lower the risk for major cardiovascular events, including MI, total stroke, and cardiovascular death. Hemorrhagic stroke occurred more often with vitamin E than with placebo (39 vs. 23 events; hazard ratio, 1.74).
The authors conclude: "These data provide no support for the use of these supplements in the prevention of cardiovascular disease in middle-aged and older men."
LINK(S):
JAMA article (Free)
Associated Press story (Free)
Previous Physician's First Watch coverage of the Physicians' Health Study II (Free)
Published in Physician's First Watch November 10, 2008
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