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High BMI, Hyperinsulinemia Associated with Prostate Cancer Mortality
Being overweight, having hyperinsulinemia, or — especially — having both increases the risk for death in men with prostate cancer, researchers report online in Lancet Oncology.
In the prospective, 24-year Physicians' Health Study, some 2500 men developed prostate cancer. In adjusted analyses, those who were overweight or obese at baseline had a higher risk for dying of prostate cancer than did normal-weight men (hazard ratios, 1.5 and 2.7, respectively). Separately, those with the highest quartile of baseline C-peptide concentration (a marker of insulin secretion) had higher prostate cancer mortality than those in the lowest quartile (HR, 2.4). Patients with both factors had four times the risk compared to men with neither factor.
The authors suggest that the tumors may progress via insulin growth factor receptors.
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Lancet Oncology article (Free abstract; full text requires subscription)
Published in Physician's First Watch October 6, 2008
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